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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CACNA1E
All Species:
12.73
Human Site:
S2174
Identified Species:
28
UniProt:
Q15878
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15878
NP_000712.2
2313
261731
S2174
R
P
L
L
S
Y
S
S
L
I
R
H
A
G
S
Chimpanzee
Pan troglodytes
XP_520396
2784
310342
G2623
S
P
L
L
S
T
S
G
A
S
T
P
G
R
G
Rhesus Macaque
Macaca mulatta
XP_001110352
2383
269535
S2171
R
P
L
L
S
Y
S
S
L
I
R
H
V
G
S
Dog
Lupus familis
XP_547425
2465
277756
P2326
R
H
S
G
S
I
S
P
P
A
D
G
S
E
R
Cat
Felis silvestris
Mouse
Mus musculus
Q61290
2272
257217
S2134
R
P
L
L
S
Y
S
S
L
M
R
H
T
G
G
Rat
Rattus norvegicus
Q07652
2222
252098
S2083
R
P
L
L
S
Y
S
S
L
M
R
H
T
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
O73700
2190
249326
D2056
H
R
S
S
W
Y
T
D
D
P
D
I
S
Y
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q2XVR3
1829
207718
I1698
K
E
E
E
R
A
A
I
A
V
Q
R
I
Y
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91645
1851
212452
H1720
K
L
N
A
S
P
T
H
T
H
H
S
T
P
H
Honey Bee
Apis mellifera
NP_001159376
1904
215872
T1773
G
G
R
Q
P
P
H
T
H
Q
H
Y
H
R
H
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001186699
1966
222605
G1835
G
G
G
G
G
G
G
G
G
S
V
T
P
R
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
47.8
95.8
90.7
N.A.
94.6
92.5
N.A.
N.A.
26.4
N.A.
20.4
N.A.
43.5
46.2
N.A.
39.5
Protein Similarity:
100
57.8
96.3
92
N.A.
95.8
93.8
N.A.
N.A.
41.9
N.A.
37.4
N.A.
55.8
57.8
N.A.
52.5
P-Site Identity:
100
33.3
93.3
20
N.A.
80
80
N.A.
N.A.
6.6
N.A.
0
N.A.
6.6
0
N.A.
0
P-Site Similarity:
100
33.3
93.3
26.6
N.A.
86.6
86.6
N.A.
N.A.
20
N.A.
26.6
N.A.
20
13.3
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
10
10
0
19
10
0
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
10
10
0
19
0
0
0
0
% D
% Glu:
0
10
10
10
0
0
0
0
0
0
0
0
0
10
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
19
19
10
19
10
10
10
19
10
0
0
10
10
37
28
% G
% His:
10
10
0
0
0
0
10
10
10
10
19
37
10
0
19
% H
% Ile:
0
0
0
0
0
10
0
10
0
19
0
10
10
0
0
% I
% Lys:
19
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
10
46
46
0
0
0
0
37
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
19
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
46
0
0
10
19
0
10
10
10
0
10
10
10
0
% P
% Gln:
0
0
0
10
0
0
0
0
0
10
10
0
0
0
10
% Q
% Arg:
46
10
10
0
10
0
0
0
0
0
37
10
0
28
28
% R
% Ser:
10
0
19
10
64
0
55
37
0
19
0
10
19
0
19
% S
% Thr:
0
0
0
0
0
10
19
10
10
0
10
10
28
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
10
10
0
10
0
0
% V
% Trp:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
46
0
0
0
0
0
10
0
19
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _